According to the MFMER (Mayo Foundation for Medical Education and Research) currently there are no effective methods of nickel allergy treatment. It is possible only to heal the skin lesions through the use of emollients (moisturizers) or preparations containing corticosteroids or calcineurin inhibitors for more serious allergy symptoms. Skin itching can be reduced by antihistamines. However, these medicines can be used for a limited period of time and they can cause side effects. It concerns in particular the steroids which increase the risk of hypertension and heart diseases, cataracts, diabetes, depression, and also the risk of osteoporosis.
The most effective and recommended by physicians method to prevention of nickel allergy is to avoid contact with the allergen, and controlling daily use items by the DMG Test. The proposed solution is also coating of metal items to form a physical barrier (protective film) between the skin and nickel ions, e.g. coating of cutlery with rhodium, sticking the tapes on clothing studs which are in direct contact with the skin, coating/lacquering of jewelry and other metal items. Manufacturers of protective coatings for stand-alone application do not guarantee absence of interactions between the product and coated item. It can result in its damage. In addition, coating of metal items is useless for people who come into contact with the allergen when performing their job duties. In order to protect skin of hands from harmful substances the solution is to use the gloves made of natural or synthetic rubber latex, and also plastic. However, long-term use may cause maceration or other skin damage. It is also estimated that about 6.4% of the population is allergic to natural rubber. Moreover, the gloves cannot be used when working with the machines with rotating elements, because it could catch the glove and crush the hand. The use of protective gloves is also uncomfortable and unaesthetic for occupational groups most exposed to the allergen, i.e. hairdressers, health care workers, receptionists, cashiers. Currently, the most common method to protect from penetration of nickel ions into the skin is the usage of barrier cosmetics, in the form cream, gel and ointment. Most of these barrier formulation are based on small and wrong substances which in complex with metal can penetrate into the skin, thus demonstrating allergic reaction. Furthermore, some of the used in barrier cosmetics compounds are no biocompatible and toxic. These preparations are not very effective, because they are dedicated not only to protect from penetration of nickel ions. The innovative solution is a new line of cosmeceuticals based on active substances dedicated especially for people with nickel allergy, which has been designed in the Research and Development Laboratory of KF Niccolum. Technology of their production is protected with a worldwide patent application, and the products are available on the market (www.nidiesque.com).